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much lower at community doses Vomiting up to 36% at high doses Diarrhea 23-26% Constipation 17-19% Fatigue 11-13% Pancreatitis risk trials flagged severe abdominal pain for discontinuation and evaluation Gallbladder issues rapid weight loss increases gallstone risk Thyroid C-cell tumors same boxed warning as semaglutide (animal studies) GI side effects were more intense than semaglutide in trial data due to the dual mechanism

To study the preventive effect of LC on peripheral neuropathy in type 2 diabetic mice, the mice were randomly divided into five groups (n=8/group): Control, diabetes, pre-treatment, treatment and post-treatment (27)

doi: 10.1016/j.pharmthera.2005.05.002 211 ChaudhriAXiaoYKleeANWangXZhuBFreemanGJ

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Main body CoQ 10 synthesis pathway The biosynthesis of CoQ 10 involves a series of intricate enzymatic steps 28