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Interestingly, SLC7A11 gene-deficient mice develop normally and healthy (Sato et al., 2005), suggesting that system x c - targeted drugs with high cancer cell selectivity have few side effects in preclinical studies

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WWTR1, interacting and modulating NF-B, a key pathway involved in inflammatory responses (Deng et al., 2018), may also modulate the astrocytic expression of pro-inflammatory cytokines, influencing the neurotoxic properties of astrocytes

Effect of N-acetylcysteine on serum antioxidant capacity Serum antioxidant capacity in the socially isolated stress group receiving normal saline was significantly reduced compared to the control group receiving normal saline

BMC Cancer 13:601 Zhdanov AV, Waters AH, Golubeva AV, Dmitriev RI, Papkovsky DB (2014) Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling