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ATP citrate lyase: A central metabolic enzyme in cancer

10.1210/endo-124-6-3050 80

Discussion The studies reviewed above collectively indicate that, while -cells have low activity of catalase and glutathione peroxidase compared to other tissues (40), they maintain a robust antioxidant system primarily requiring the cytoplasmic thioredoxin reductase 1 (TXNRD1), thioredoxin 1 (TXN1), and peroxiredoxin 1 (PRDX1)

AHK-Cu reduced PARP cleavage fragments by 77.5%, confirming reduced cell death

Additionally, this axis, when excessively activated in endothelial cells, suppresses VEGFR2 phosphorylation and induces degradation of tight junction proteins (such as occludin), compromising the blood-nerve barrier (Stirban et al., 2014)