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This interaction results in the upregulation of Gln transporters SLC38A2 and SLC7A5, facilitating Gln uptake by lung cancer cells and promoting tumor proliferation ( Gln enters cells through transporters such as SLC1A5, SLC38A2, and SLC7A5

The ability of these compounds to modulate multiple aspects of AD pathology makes them valuable candidates for future therapeutic interventions

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For people with type 2 diabetes, the SURPASS trial series demonstrated exceptional glycemic control alongside weight loss, which is why the compound received its first approval for diabetes before the obesity indication followed