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These findings have led to the hypothesis that DSIP may play a role in influencing circadian and sleep-wake regulatory mechanisms in non-human research subjects in preclinical trials

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Further clinical studies are warranted to validate its long-term safety, optimal dosing, and therapeutic efficacy in human subjects

J Trace Elem Med Biol 73:127044 Sabry W, Elemary M, Burnouf T, Seghatchian J, Goubran H (2020) Vitamin B12 deficiency and metabolism-mediated thrombotic microangiopathy (MM-TMA)

[166] : 161 [178] [132] In April 2020, BioNTech signed a partnership with Pfizer and received $185 million, including an equity investment of approximately $113 million