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DOX upregulates the expression and activity of FDX1, a reductase that converts accumulated Cu to the more reactive Cu [77]

Examined in oxidative stress response models: Oxidative stress contributes to telomere shortening and cellular damage

Weight-based dosing calculations sometimes appear in discussions, with suggestions of approximately 2.5 to 5 mcg per pound of body weight daily

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Caloric restriction (CR) is the most reliable intervention to regulate aging and increase the healthy lifespan in diverse species, including rodents and non-human primates [105] and FOXO proteins are thought to play a critical role in mediating the effects of CR