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in which 56 patients with acute ischaemic stroke underwent recanalisation therapy (30 with intravenous thrombolysis, 15 with mechanical thrombectomy, and 11 with both methods combined) revealed that the plasma levels of isovalerate, one of the SCFAs, were inversely correlated with stroke severity as measured by the National Institutes of Health Stroke Scale (NIHSS) both on admission and at discharge, while TMAO levels were not associated with stroke severity (as measured by the NIHSS) or functional outcome (as measured by the Modified Rankin ScalemRS) [57]

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[DOI] [PubMed] [Google Scholar] 64.Jain S.K., Velusamy T., Croad J.L., Rains J.L., Bull R

however, these findings have not yet been consistently replicated in human trials

Targeting metabolic-redox circuits for cancer therapy