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Early reports that Kupffer cell-induced oxidant stress and peroxynitrite formation may cause APAP-induced injury [92, 93] were questioned as the data could not be reproduced [9496], NADPH oxidase-deficient mice were not protected [97, 98] and mitochondria in centrilobular hepatocytes were identified as the main source of superoxide and peroxynitrite under these conditions [72, 99]

282 These cytokines sensitize nociceptive neurons, leading to neuropathic pain, and promote neuronal damage through demyelination and axonal degeneration

Because NKX21 copy number gains also have been identified in LUAD and NEPC, we investigated whether NKX21 associated elevation of serine/glycine synthesis enzyme expression is uniformly observed across all cancer types

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