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Collectively, these advancements underscore the potential of ferroptosis as a therapeutic target and highlight the importance of integrating innovative technologies to improve outcomes in GBM treatmentHowever, clinical translation faces hurdles, including GBM heterogeneity, the TME, and lack of reliable biomarkers

These CGs were prioritised based on their functional annotations and recurrence across multiple expression datasets

In addition, insulin administration is known to result in increased GST gene expression through the PI3K/AKT/mTOR pathway and reduced intracellular oxidative stress, while glucagon decreases such gene expression