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Elevated calcium levels activate calpains and other calcium-dependent enzymes, which impair mitochondrial function and contribute to neuronal injury

Liu W, Li W, Wang P, Zhang H, Zhang E, Wu X, et al

Patients receiving SGLT2is and GLP-1 RAs exhibited comparable rate of any DR (subdistribution hazard ratio [SHR], 0.90

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To mimic the trimerized conformation of the native SARS-CoV-2 spike glycoprotein more closely, they fused naturally trimerized human resistin to the spike ectodomain to generate a stable trimer protein antigen called SmT1