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Patients with chronic kidney disease, dialysis needs, or advanced liver conditions should only consider IV infusion under close medical supervision

Methods This research complies all relevant ethical regulations

Key Differences: Injection Glutathione vs Oral or Topical Why Risks Increase Because injection bypasses natural barriers and goes straight into the bloodstream, any impurity, contamination, or incorrect dosing/administration can cause serious harm unlike oral or topical use which are inherently less invasive

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Conclusion: CTSD may be a possible biomarker of severe NAFLD since its hepatic/adipose tissue expression as well as circulating levels correlated with liver damage thus allowing to discriminate advanced disease