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When excess hepcidin is transferred to the extracellular space, it inhibits the release of Fe 2+ from the cell, ultimately leading to ferroptosis

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway

References 1 LeriMScutoMOntarioMLCalabreseVCalabreseEJBucciantiniMet al

Therefore, an increase in labile iron pool and lipid peroxidation are considered typical presentations of ferroptosis and are used as markers of ferroptotic cell death (Fig