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LT stress has a significant effect on plant growth and developmental processes

Long term safety data indicated no adverse clinical or biochemical effects in 1039 individuals taking paracetamol 19504000 mg daily for up to 1 year 39 or 178 patients taking 2600 mg day 1 of paracetamol for 2 years in osteoarthritis trials 40

10.1016/j.molstruc.2013.01.049 37 GaoT

However, this is a matter of debate since there are conflicting results and it is still uncertain whether vitamin E protects against liver injury caused by APAP [7476]