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This selective mechanism produces metabolic safety benefits that may make AOD-9604 appropriate for individuals who cannot tolerate or have contraindications to conventional growth hormone therapy

PubMed 22962027 TB-4 Phase 1 human safety first-in-human randomized, double-blind, single- and multiple-dose Phase 1 of recombinant human thymosin 4 in healthy volunteers, no serious adverse events: PubMed 34346165

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However, it is important to note that hydroxocobalamin is not effective in treating pernicious anemia, which is caused by an autoimmune disorder

design factorial studies and confirm pathway engagement