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Epigallocatechin-3-gallate reduces retinal ischemia/reperfusion injury by attenuating neuronal nitric oxide synthase expression and activity

Under normal physiological conditions, oxidative stress plays an active role in adaptive stress responses (e.g., NAFLD detoxification, molecular damage repair, anti-inflammation, and tissue regeneration), such as by promoting cell autophagy and mitochondrial autophagy, which can effectively deal with acute exposure to cellular stressors

Niacin deficiency often associated with malnutrition is observed in the homeless population, in individuals suffering from anorexia nervosa or obesity, and in consumers of diets high in maize and poor in animal protein (26-29)

Resveratrol attenuates NF-B activation by blocking the phosphorylation and degradation of its inhibitory subunit, IB, thereby preventing nuclear translocation of the NF-B p65 subunit, which reduces the expression of inflammatory cytokines, including IL-1, IL-6, and TNF- (93)

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