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For over a decade, it has been known that dietary collagen supplementation (rich in GLY) strongly potentiates glucose-stimulated insulin secretion in patients with T2D [79]

Briefly, M2 phenotype macrophages would be preferentially endowed with potentials to promote the motility of cancer cells in invasion areas [57], to promote metastasis in stromal and perivascular areas [31], and to stimulate angiogenesis in avascular and peri-necrotic hypoxic areas [54]