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Extramitochondrial frataxin has been shown to physically interact with IscU1, the cytosolic isoform of the human ISC, indicating a role for frataxin in the Fe/S cluster assembly in the cytosol (Acquaviva et al., 2005)

Chronic inflammatory diseases: Autoimmune diseases : Rheumatoid arthritis, lupus, and inflammatory bowel disease involve heightened immune responses and oxidative stress, both of which can be worsened by glutathione deficiency

This review article aims to describe the mechanisms of action of UroA and spermidine not only on the maintenance of cellular health, which is mediated by the induction and maintenance of autophagy and mitophagy, but also on their potential clinical relevance

This creates a vicious cycle where mitochondrial injury triggers inflammation, which causes further oxidative stress, which in turn causes even more mitochondrial damage

However, at 144 hpf, thyroid tissue appeared enlarged in around 55% (170/312) of the nrf2a crispants compared with their adamtsl2 crispants and noninjected siblings (Fig S1IL)