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In DPPOS year 9, vitamin B 12 deficiency rates were 4.4%, 5.9%, and 4.9% for GG, AG and AA genotype groups in the placebo arm, vs 5.7%, 6.6%, and 18.7% in those respective genotype groups in the metformin arm (ESM Table 9)

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Western blot Cells were harvested and proteins were extracted using cell lysis buffer supplemented with 0.3% phenylmethylsulfonyl fluoride and proteinase and phosphatase inhibitors

Alm disso, nenhum efeito mutagnico ou genotxico foi relatado nos testes padro