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This gut-lung interorgan communication mechanism demonstrates significant clinical relevance in chronic respiratory diseases, with large-scale cohort studies establishing a strong inverse correlation between gut microbiota -diversity reduction and key clinical parameters including asthma exacerbation frequency and annual lung function decline in COPD (Tangedal et al., 2024)

doi: 10.1016/j.plantsci.2016.09.002 110 WawrzyskaA.PiotrowskaJ.ApodiakouA.BrcknerF.HoefgenR.SirkoA

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