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A number of extracellular antioxidant proteins have been described to localize to the ECM of the lung, suggesting a potential protective role in presence of oxidative stress 31 , in particular, glutathione peroxidase 3 (GPX3) and extracellular superoxide dismutase (EC-SOD or SOD3) 26,27,28,32,33

A 12-week phase 2a trial reported that 60% of gaboxadol-treated individuals with fragile X syndrome (FXS) were CGI-I responders

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toxic metabolite formation or reduced glutathione stores, the reactive metabolite is free to covalently bind to vital proteins and the lipid bilayer of hepatocytes

The telogen phase typically lasts around three months