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Dose selection lacks standardization: Carroll et al (85) found efficacy with 4 g/day curcumin, whereas a larger trial by Cruz-Correa et al (87) showed no benefit at 480 mg/day, highlighting the need for pharmacokinetic-guided individualized dosing

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Histamine binding to H 2 receptors can activate PKA and induce tyrosinase pathway, and therefore melanogenesis process (Malaviya et al., 1996