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Although the signaling pathways leading to the progression of apoptosis have been extensively characterized, recent studies highlight the regulatory role of changes in the intracellular milieu (permissive apoptotic environment) in the efficient activation of the cell death machinery

Till date, eight different isozymes, viz., GPx1-GPx8, have been identified in humans, of which GPx1, GPx2, GPx3, GPx4, and GPx6 are selenoenzymes containing Sec in their active site (Table 1) [1, 8, 9]

225 Meanwhile, this is also an important mechanism for the body to eliminate senescent cells in type 1 diabetes

J Pers Med (2020) 10:192

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