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Astrocytes regulate glutamate clearance and metabolic support to neurons, and disruption of these functions promotes excitotoxic stress and increases neuronal vulnerability [5]

doi: 10.1128/jb.172.3.1409-1417.1990 33 EhrhardtD

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The group also synthesized additional variants, L3 and L4 , in which Lys60 was replaced with shorter Lys analogs, ornithine (Orn) and diaminobutyric acid (Dab), respectively, followed by lactamization