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Nature 493, 679683 10.1038/nature11745 [DOI] [PMC free article] [PubMed] [Google Scholar] 62.Kalender A., Selvaraj A., Kim S.Y., Gulati P., Brule S., Viollet B.et al

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see Additional file 1: Table S5)

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Th1 and Th17 cells secrete cytokines that disrupt the tight junctions of the bloodbrain barrier (BBB), allowing inflammatory factors such as TNF, IL-1, and IL-6 to enter the brain, thereby accelerating the progression of AD

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