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[15] Methodological issues with the clinical trials prevent firm conclusions, and the review authors stated: "No definitive conclusion can currently be drawn" and there is "no definitive evidence that MSM is superior to placebo in the treatment of mild to moderate osteoarthritis of the knee." [16] Contraindications and safety [edit] In July 2007 a manufacturer of MSM submitted a notification to the U } : CS1 maint: DOI inactive as of July 2025 (link) Oyo Yakuri Pharmacometrics

It is most commonly associated with increased sebum production in the sebaceous glands, abnormal hyperkeratinization of the hair follicles and their excessive colonization by C

Quintana-Cabrera R, Quirin C, Glytsou C, Corrado M, Urbani A, Pellattiero A, et al

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