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Similarly, we have reported in the present work that children born to parents with obesity, who had higher HOMA-IR scores, manifested worsened impairments in steroid derivatives, further emphasizing the potential involvement of IR in driving these PO-related metabolic disruptions

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This finding aligns with our structural analysis, indicating that C34 and C37 Fab molecules block Mxra8 binding by clashing with the stalk region of CHIKV E