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Conversely, Helional activates OR2J3 on A549 cells, triggering PI3K pathway activation, which leads to apoptosis and proliferation inhibition (72), highlighting the differential effects of ligands on the same receptor in different cell types

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Astrocytes and oligodendrocytes, which are highly metabolically active cells in the brain, may experience disrupted iron homeostasis, leading to impaired normal neural function, especially given their high sensitivity to oxidative stress

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