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Higher concentrations of doxorubicin were found to result in elevated OXPHOS activity, upregulation of P-gp, and drug resistance in osteosarcoma cells (Zhao et al., 2023)

However, animal studies raise the prospect of oxidative stress-mediated mitochondrial dysfunction in inducing neurotoxicity

Nature 266:565567 Xu D, Trmulot L, Yang Z, Mhamdi A, Chtel-Innocenti G, Mathieu M, Espinasse C, Van Breusegem F, Vanacker H, Issakidis-Bourguet E, Noctor G (2025) Cytosolic monodehydroascorbate reductase 2 promotes oxidative stress signaling in Arabidopsis

1981;304:170171 Barton JC, Acton RT