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Mechanisms involved in the transport of mercuric ions in target tissues

If lymph flow is restricted or impaired to a limb or specific body area, the leg or arm will swell and harden over time

Patients should be referred urgently if they have neurological symptoms, if the diagnosis is unclear, or if there is inadequate clinical response to treatment

Survivors and those presenting later in life develop progressive hematopoietic, neuroendocrine, and other systemic organ failure (Kearns-Sayre syndrome)