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Simultaneously, the opening of the mitochondrial permeability transition pore induces mitochondrial swelling and rupture, releasing apoptotic factors and ultimately leading to cell death [34, 35]

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PLoS One 9:e100725 Soltaninassab SR, Sekhar KR, Meredith MJ, Freeman ML (2000) Multifaceted regulation of -glutamylcysteine synthetase

The median spiny neurons of the midbrain are the primary targets of PD, but additional losses of dopaminergic neurons and accumulation of Lewy bodies in the substantia nigra pars compacta (SNpc) affect normal physiological neuronal functioning