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These enzymes can either detoxify drugs/xenobiotics by converting them into less harmful compounds 0.4-NP is a potent inhibitor to these cytochrome P 450 enzymes CYP1A2, CYP2C19, and CYP2D6 causing toxicity in the body of any organism which is exposed to any kind of xenobiotics or pollutants

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Further studies should aim to establish whether these metabolomic changes are causal in AF development and whether dietary interventions to restore metabolomic homeostasis could be a viable therapeutic strategy

Liu Y., Cui D., Hoshii Y., Kawano H., Une Y., Gondo T., Ishihara T