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2018;98:6249 Medical Journals/Acta D-V

However, the persistence of CAR T cells will be limited if they become infected

This is an important factor leading to tumor drug resistance, metastasis and recurrence

In addition, animal experiments and cell experiments have confirmed that berberine reduces the levels of extracellular and intracellular A, increases the levels of LC3-II, Beclin-1, hVps34 and cathepsin-D, and reduced the levels of P62, Bcl-2, amyloid precursor protein (APP), and beta-secretase 1 (BACE1)