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These cytokines disrupt the production of key ECM proteins, including collagen type II and aggrecan, while promoting the synthesis of matrix metalloproteinases (MMPs), which leads to ECM degradation and further progression of OA [2]

Therefore, mitochondrial metabolic rewiring not only sustains cellular homeostasis but also functions as a pivotal node in immunometabolic cross-talk, contributing to the pathogenesis of chronic inflammatory disorders (such as RA)