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Acknowledgements This work was supported by the National Science and Technology Major Projects (2008ZX10002003, 2012ZX10002002004, 2012ZX10004701, 2013ZX1000200, and 2017ZX10202201002)

2.3 Amino acid metabolism and antioxidant systems regulate ferroptosis Abnormal amino acid metabolism leads to the inactivation of antioxidant systems, and the accumulation of lipid peroxidation products is regulated by antioxidant systems, which are considered critical determinants of whether ferroptosis occurs