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In the SURMOUNT-1 trial, published in The New England Journal of Medicine (2022), people lost up to 22.5% of their body weight over 72 weeks

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Factors such as oxidative stress, dysregulation of adipocytokines, the inflammasome, anti-inflammatory modulators, and the presence of comorbidities may be related to the development of inflammation-associated airway remodeling in individuals with asthma and obesity

(96) identified elevated levels of ATF4 in human glioblastoma, and pharmacological or genetic inhibition of System X c - can attenuate ATF4-induced cancer cell proliferation