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doi: 10.1159/000057700 62 VermaDKGuptaSBiswasJJoshiNSinghAGuptaPet al

Figures 1 4 )

These mutations disrupt electron transfer between complex Is Fe-S center and CoQ10, causing excessive reduction of Fe-S clusters, electron leakage, and increased production of oxygen radicals ( External factors like immune responses and inflammation often induce mitochondrial oxidative damage