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Collectively, these findings suggest that carefully regulated caffeine intake may support certain aspects of post-stroke recovery, particularly by modulating neuroinflammation and enhancing neural responsiveness, although further studies are needed to define optimal therapeutic windows and dosing strategies

Moreover, no signs of inflammation were observed in nasal mucosa of co-modified-BM-loaded PLGA-treated mice, suggesting a safe and non-invasive strategy for intranasal delivery 127

Nonetheless, direct evidence of PLA2 family enzymes controlling PE-AA levels and playing an important role in ferroptosis remains scarce