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In support, re-analysis of the RNA-seq data in Helminen dataset 94 (supplementary Fig

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The rationale for using multiple chelators is so the individual dose of each agent can be lower, which reduces the risk of adverse events without decreasing clinical efficacy (Grady 2012)

However, further research is needed to understand the specific effects of KO on the skin under environmental stress and its potential to improve skin condition, as well as to elucidate the molecular mechanisms underlying the multiple benefits of KO on skin health

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