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While L-kynurenine is of interest as it is a precursor of NAD + in eukaryotes (Figure 2) [80,81], our focus is on KYNA, made via the terminal stages of the pathway leading to KYNA from tryptophan (Figure 3), which goes via N-formyl kynurenine and L-kynurenine, and thus consists of three enzymes

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The findings were inconsistent in plasma where two studies reported higher activity in cases than controls [72, 81] and two reported lower activity [71, 83]

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