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For more details, see reference ( The final section will focus on the MM environment, with particular attention to the bone marrow (BM) niche, aiming to identify new players and leverage their unique properties to enhance tumor eradication

A response observed in one model should therefore not be generalized to another model without confirming transporter context, intracellular carnitine status, and functional oxidation readouts

Testing increasing concentrations of DZnep on these transgenic embryos revealed clear similarity to the effects of DZnep on circadian clock markers, resulting in the lengthening of the somite segmentation clock period (Supplementary Fig

These bioactive compounds play crucial roles in maintaining metabolic homeostasis, immune regulation, and endocrine function through multiple interconnected mechanisms ( At the mechanistic level, dysregulation of SCFAs contributes to the pathogenesis of PCOS through multiple pathways: first, decreased SCFAs (including butyrate) reduce the expression of intestinal tight junction proteins, increasing gut permeability and allowing LPS translocation into circulation, which triggers chronic low-grade inflammation

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