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Your first appointment at our Winter Park clinic includes a consultation with a medical provider, a review of your health history, and diagnostic testing if needed

Statements Author contributions YuH and YR drafted this manuscript, YM, DC, TZ, SF, WL, YiH, HL helped to revise the manuscript, J-FX, JP and BZ helped to revise the manuscript and were responsible for leading this work

68% had decompensated cirrhosis, 20% had HCC, 8% FHF

Zhou L, Too HP (2013) GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFR2 and RET

Introduction -thalassemia is the most common inherited disease, characterized by decreased or absent -globin chain synthesis and hemoglobin A production ( The incidence of myocardial iron overload in transfusion-dependent -thalassemia patients has increased from 11.4%15.1% in early studies to 26.1%36.7% in recent studies ( As iron loading progresses, the capacity of transferrin to bind and detoxify iron is eventually exceeded, leading to non-transferrin-bound iron in plasma, which promotes oxidative stress, mitochondrial dysfunction, and ferroptosis ( Mechanisms of myocardial injury caused by iron overload Studies have shown that iron myocardial overload causes myocardial dysfunction