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Under normoxic conditions, the alpha subunits of HIF are usually targeted for ubiquitination by the hydroxylation of prolyl particles and, later, are connected with von Hippel Lindau (VHL) proteins, leading to end-stage HIF alpha subunit degradation

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In addition, for patients with unresectable HCC at the current stage, the primary treatment options include local ablation, chemotherapy, radiotherapy, and interventional embolization, with transcatheter arterial embolization (TACE) being the most widely employed in clinical medicine