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Impact of eugenol on in vivo model of 6-hydroxydopamine-induced oxidative stress

After 15 passages (generations), we assessed the responses of normal and resistant populations to TMZ and EP treatment and characterized expression of important genes and proteins in cellular signaling pathways known to be associated with multi-drug resistance in GBM

Some patients may experience minimal benefit or no benefit from peptide therapy

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Given that the cellular thiol network, including GSH, involves crosstalk between the cytosol and organelles, we selected two of the dysregulated enzymes, which had been identified by 2D electrophoresis, with important roles in mitochondrial function, i.e., Aco2 and mitochondrial creatine kinase (mtCK) (Fig