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This is illustrated in a study showing that in LPS-induced macrophages, although the rate of glucose consumed was the same as resting macrophages, the rate of lactate produced was much higher, indicating increased glycolysis while suppressing mitochondrial glucose metabolism (ONeill and Hardie, 2013)

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One of the important arguments against late treatment is the fact that the peak of ROS generation (induced by noise exposure) appears within a short time after noise exposure and not after 7 days