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reported that phage therapy alleviates colitis-related outcomes by modulating both the gut microbiome and host immune responses 229

Lots of drugs or strategies have been developed and applied on clinical trial ( Table 3 ), such as DMARDs, biologic agents, TCM, cell transfer, gene therapy, vaccine and nano drug delivery system, to treat RA with both advantages and shortcomings

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These are mechanisms whereby microglia can accelerate neurodegeneration in models of HD and tauopathy by compromising neuronal proteostasis, driving the accumulation of the disease-causing protein

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