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Peretinoin, a synthetic retinoid, revealed a potential to inhibit hepatocarcinogenesis by downregulation of sphingosine kinase 1, which resulted in hindering cancer progression (76)

For enhanced apoptotic effect, Y-H transition inhibitors can be combined with apoptosis-inducing drugs for the downregulation of common signal transducers (NADP-GDH, ODC, etc.)