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Moreover, rigorous kinetic analysis using model didpeptide and protein sulfenic acid shows that, by itself, 1,3-CPD reacts 20-fold slower than dimedone (ostensibly due to the stabilization of the carbanion in 1,3-CPD)

Therefore, when using metal chelators for diseases characterized by excess Cu intake, one must consider carefully their potential risk of neurotoxicity or loss of essential metals