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FIGURE 1 4 Role of natural products 4.1 Herbal products 4.1.1 Baicalein Baicalein is a chemical compound derived from the dried root of the Scutellaria baicalensis plant (Labiatae) (Li et al., 2012)

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For reference, the IC 50 of the selected linear peptide without TBMB modification was greater than 10 M, which highlights the superior therapeutic potential of cyclic peptides compared to their linear counterparts 6

We investigated the impact of anti-alpha1/alpha2/beta1/beta2 receptor, Endothelin B receptor, Angiotensin II receptor Type 2, and CXCR3 receptor directed RABs on clinical outcomes after first ischemic stroke