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Obese human and animal models are generally accompanied with abnormal circulating IGF-1 levels [130], as well as IGF-1/IGFBP-3 ratio

doi: 10.1093/occmed/kqg048

Given the observation that lactate was enriched in the inflamed tissues, researchers believed it to be an inhibitor of inflammatory cytokines production and degranulation of mast cells, dependent on MCT1 expression [112]