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PDB would only occur if the two enzyme halves are brought in close proximity, for example via the interaction of the two fused proteins

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases

R.DikshitP.GoswamiA.KotliarovaS.MurataS.TanakaK.et al (2005)

FIGURE 18 Curcumin-based platinum(II) complexes have been proposed as promising strategies to overcome some of the limitations associated with both free curcumin and conventional platinum drugs such as cisplatin